#Parkinson's disease is associated with early parasympathetic dysfunction leading to constipation and gastroparesis. The positron emission tomography tracer 5-[(11)C]-methoxy-donepezil was recently validated for imaging acetylcholinesterase density in the brain and peripheral organs.
#Donepezil is a high-affinity ligand for #acetylcholinesterase-the enzyme that catabolizes acetylcholine in cholinergic synapses. Decreases in (11)C-donepezil binding may, therefore, represent a marker of parasympathetic denervation of internal organs.
Donepezil PET-Notes Reviewed by Sumer Sethi on Monday, March 16, 2015 Rating: