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Paget's Disease

Paget’s disease of bone (PDB) is a localised disorder of bone remodelling, characterised by enhanced resorption of bone by giant multinucleated osteoclasts followed by formation of disorganised woven bone by osteoblasts. The resultant bone is expanded, weak and vascular, causing bone pain brittleness and deformity.
Paget's Disease Reviewed by Sumer Sethi on Friday, March 05, 2010 Rating: 5

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