Zinc-sensitive MRI contrast agent in prostate: Potential Use in Future
In an article published in PNAS vol. 113 no. 37, M. Veronica Clavijo Jordan, E5464–E5471 by M. Veronica Clavijo Jordan use of since sensitive MR contrast media has been advocated as a potential future role in differentiating prostatic lesions.
"Authors demonstrated that secretion of Zn(II) ions from normal, healthy prostate tissue is stimulated by glucose in fasted mice and that release of Zn(II) can be monitored by MRI. They observed 50% increase in water proton signal enhancement is observed in T1-weighted images of the healthy mouse prostate after infusion of a Gd-based Zn(II) sensor and an i.p. bolus of glucose. The agent proved successful in detecting small malignant lesions as early as 11 wk of age, making this noninvasive MR imaging method potentially useful for identifying prostate cancer in situations where it may be difficult to detect using current multiparametric MRI protocols."
Zinc-sensitive MRI contrast agent in prostate: Potential Use in Future
Reviewed by Sumer Sethi
on
Monday, September 26, 2016
Rating:
Reviewed by Sumer Sethi
on
Monday, September 26, 2016
Rating:
Sumer Sethi
Unique blend of academic excellence and entrepreneurship, heading leading firms in India- Teleradiology Providers, pioneering company providing teleradiology services and DAMS (Delhi Academy of Medical Sciences) Premier test preparation institute in India for MD/MS/MCI preparation. He has also been an invited faculty member at various conferences, including Teleradiology in IRIA 2008 and 2011, Hospital Build Middle East, Congress of the Brain Tumor Radiology in Neuro-oncology Society. Dr. Sethi is Editor-in-Chief of Internet Journal of Radiology. He has a keen interest in Web 2.0 technologies and in maintaining his famous radiology blog, which has been featured in multiple international journals.
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