Zinc-sensitive MRI contrast agent in prostate: Potential Use in Future
In an article published in PNAS vol. 113 no. 37, M. Veronica Clavijo Jordan, E5464–E5471 by M. Veronica Clavijo Jordan use of since sensitive MR contrast media has been advocated as a potential future role in differentiating prostatic lesions.
"Authors demonstrated that secretion of Zn(II) ions from normal, healthy prostate tissue is stimulated by glucose in fasted mice and that release of Zn(II) can be monitored by MRI. They observed 50% increase in water proton signal enhancement is observed in T1-weighted images of the healthy mouse prostate after infusion of a Gd-based Zn(II) sensor and an i.p. bolus of glucose. The agent proved successful in detecting small malignant lesions as early as 11 wk of age, making this noninvasive MR imaging method potentially useful for identifying prostate cancer in situations where it may be difficult to detect using current multiparametric MRI protocols."
Zinc-sensitive MRI contrast agent in prostate: Potential Use in Future Reviewed by Sumer Sethi on Monday, September 26, 2016 Rating: