Hypothalamic Hamartoma-MRI
26 yrs old lady with seizures shows a well defined iso-intense to grey matter on all sequences nodular lesion in the tuber cinereum suggesting hamartoma
Teaching points by Dr MGK Murthy, Mr Samuel
1. Tuber cinereum a component of Hypothalamus ,is a hollow eminence of grey matter between optic chasm and mammillary bodies with tuber nucleus and tubero mammillary nucleus (Produces Histamine in the brain) as constituents , serving to maintain Circadian Rhythm
2. Hamartoma (benign non neoplastic proliferating cells ) can produce gelastic (gelos= laugh) seizures and precocious puberty
3. MR delineates the lesion well with anterior border as lamina terminals and lateral as Anterior perforated substance , with stalk extending from it to the pituitary
4. Contrast study though is suggested to exclude hypothalamic Glioma (Differential diagnosis), does not show enhancement
4. Associated anomalies like Anal atresia, renal anomaly (like horseshoe),polydactyly, bifid epiglottis is known as Pallister-Hall syndrome
Hypothalamic Hamartoma-MRI
Reviewed by Sumer Sethi
on
Tuesday, April 28, 2015
Rating:
Reviewed by Sumer Sethi
on
Tuesday, April 28, 2015
Rating:
Sumer Sethi
Unique blend of academic excellence and entrepreneurship, heading leading firms in India- Teleradiology Providers, pioneering company providing teleradiology services and DAMS (Delhi Academy of Medical Sciences) Premier test preparation institute in India for MD/MS/MCI preparation. He has also been an invited faculty member at various conferences, including Teleradiology in IRIA 2008 and 2011, Hospital Build Middle East, Congress of the Brain Tumor Radiology in Neuro-oncology Society. Dr. Sethi is Editor-in-Chief of Internet Journal of Radiology. He has a keen interest in Web 2.0 technologies and in maintaining his famous radiology blog, which has been featured in multiple international journals.
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