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Radiology of Alzeimer's Dementia

ü  The disease is named after Aloïs Alzheimer, who first described senile plaques and neurofibrillary tangles in a 51-year-old woman in 1906.
ü  Coronal MRI images perpendicular to the long axis of the temporal horn should be used to determine the amount of hippocampal and medial temporal lobe atrophy (MTA).
ü  The process usually starts in the medial temporal lobe (entorhinal cortex and hippocampus) or the posterior cingulate, and then spreads to the tempoparietal cortex.

ü  In younger subjects with AD, the hippocampus may be spared, with pathology dominating in the precuneus (including posterior cingulate) and parietal cortex
Radiology of Alzeimer's Dementia Reviewed by Sumer Sethi on Wednesday, October 15, 2014 Rating: 5

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