Thursday, April 21, 2011

Gadolinium For Radiologist




 This is a supplement to our previous post on  MRI contrast media, submitted by Dr MGK Murthy.
  • Chemical element with Atomic No 64 in periodic table in lanthanide series  
  • Atomic weight of 157.25g.mol_1 
  • malleable 
  • world produces pure gadolinium of appx 400 tonnes  
  • because of nature of high absorption of neutrons used in nuclear medicine 
  • because of paramagentic properties used in MRI for contrast after chelating, as free gadolinum is toxic
Recommendation with no bias for any specific chemical or marketing production houses :

 

  • If the patient has normal renal function, use of any gadolinium compound makes no difference as renal excretion gets it out of the body 
  • If the patient has moderate renal dysfunction, use of less dose, interval of at least 7days between repeat doses and preferable use of macromolecule varities would help 
  • If the patient has severe renal dysfunction, use of macromolecules would be advised
  • In extremes of age and lactating mothers , macromolecules is recommended
  • If the patient has Calculated GFR of < 30ml/mt/1.73m2, Gadolinuim use is prohibited
  • In pregnancy , Gadolinium is contraindicated

2 comments:

Anonymous said...

NSF has been observed in patients with normal kidney function

Anonymous said...

NSF has been DIAGNOSED in patients with NORMAL KIDNEY FUNCTION

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