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Significance of DWI hyperintensity in splenium

This is a case of 38 yr old female who presented to us with a history of convulsions. MR imaging brain was performed and a small focus of splenium hyperintensity is noted on diffusion weighted and slightly hyperintense on FLAIR images.
Focal splenial hyperintensity has been reported in patients with clinically mild encephalitis/encephalopathy, epilepsy, in association with antiepileptic drug, acute cerebellitis, and stroke-like episodes. In a study by Bulakbasi et al, AJNR 27: 1983-86, transient lesion of splenium of corpus callosum (SCC) is a significant but nonspecific finding. It is probably due to inflammatory changes of the splenium and may be only detectable change in patients with good prognosis, indicating a clinically mild form of encephalitis/encephalopathy. Clinically all patients recover on days 4-9.
Significance of DWI hyperintensity in splenium Reviewed by Sumer Sethi on Friday, November 27, 2009 Rating: 5

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