Recent evidence supports that the prevalence of patent foramen ovale is higher in patients with migraine with aura. Tatlidede AD et al conducted a case-control study and searched for intra-atrial right to left shunt in 53 patients with migraine. PFO was detected by means of transthoracic echocardiography with administration of contrast medium during valsalva maneuver and the results were compared with age and sex matched 27 healthy controls. Patent foramen ovale was more frequent in the migraine group.
Reference- Agri 2007 Oct;19(4):39-42
However in Circulation 2008 Sep 30;118(14):1419-24. Epub 2008 Sep 15. Paper titled-Patent foramen ovale and migraine: a cross-sectional study from the Northern Manhattan Study (NOMAS), authors didnot find aassociation significant. According to them, The causal relationship between PFO and migraine remains uncertain, and the role of PFO closure among unselected patients with migraine remains questionable.