Monday, October 20, 2008

Journal Club-Patent Foramen ovale and Migraine

Recent evidence supports that the prevalence of patent foramen ovale is higher in patients with migraine with aura. Tatlidede AD et al conducted a case-control study and searched for intra-atrial right to left shunt in 53 patients with migraine. PFO was detected by means of transthoracic echocardiography with administration of contrast medium during valsalva maneuver and the results were compared with age and sex matched 27 healthy controls. Patent foramen ovale was more frequent in the migraine group.
Reference- Agri 2007 Oct;19(4):39-42
However in Circulation 2008 Sep 30;118(14):1419-24. Epub 2008 Sep 15. Paper titled-Patent foramen ovale and migraine: a cross-sectional study from the Northern Manhattan Study (NOMAS), authors didnot find aassociation significant. According to them, The causal relationship between PFO and migraine remains uncertain, and the role of PFO closure among unselected patients with migraine remains questionable.


Anonymous said...

Dear Sumer,

I am glad to see your post about PFO and migraine. While there is much controversy about the relation of PFO and migraine, I wish to share my experience. I participated in the now defunct ESCAPE trial. I went from suffering 11-14 migraines a month, including hemiplegic migraine, to zero. I have not had a single migraine since undergoing the procedure. This has been a miracle for me.

Anonymous said...

Wow. That is great! Did you have aura with your migraine? It seems like the aura migraine is more highly associated with the PFO closure being successful. I have about 25 migraine days a month, but often without migraine. I am always looking for a cure.

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