In 1903 Marchiafava and Bignami, 2 Italian pathologists, described 3 men with alcoholism who died after having seizures and coma. In each patient, the middle two thirds of the corpus callosum were severely necrotic. Most patients are men with alcoholism. In some cases, the damage extends to areas such as the nearby subcortical white matter, the anterior commissure, or both. These are FLAIR, Sagittal and Diffusion weighted images of a 50 year old chronic alcoholic showing corpus callosal necrosis.
Dr.Sumer K Sethi, MD
Sr Consultant Radiologist ,VIMHANS and CEO-Teleradiology Providers