Wednesday, March 19, 2008

Response Evaluation Criteria in Solid Tumors

Methods of Measurement
CT and MRI are the best currently available and reproducible methods to measure target lesions selected for response assessment. Lesions on chest X-ray are acceptable as measurable lesions when they are clearly defined and surrounded by aerated lung. However, CT is preferable.
Baseline documentation of “Target” and “Non-Target” lesions
All measurable lesions up to a maximum of five lesions per organ and 10 lesions in total, representative of all involved organs should be identified as target lesions and recorded and measured at baseline. A sum of the longest diameter (LD) for all target lesions will be calculated and reported as the baseline sum LD. The baseline sum LD will be used as reference by which to characterize the objective tumor. • All other lesions (or sites of disease) should be identified as non-target lesions and should also be recorded at baseline. Measurements of these lesions are not required, but the presence or absence of each should be noted throughout follow-up.

Response Criteria
Complete Response(CR):
Disappearance of all target lesions
Partial Response (PR): At least a 30% decrease in the sum of the LD of target lesions, taking as reference the baseline sum LD
Progressive Disease (PD): At least a 20% increase in the sum of the LD of target lesions, taking as reference the smallest sum LD recorded since the treatment started or the appearance of one or more new lesions
Stable Disease (SD): Neither sufficient shrinkage to qualify for PR nor sufficient increase to qualify for PD, taking as reference the smallest sum LD since the treatment started


Reference-

2 comments:

HLauro said...

For more information on topics such as this please join us at our 12th Annual Clinical Magnetic Resonance Society Meeting, June 26 - 29, 2008 at Disney's Board Walk Resort in Lake Buena Vista, Fl.

www.cmrs.org
813-806-1080

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