In Vivo 18 F-Fluorodeoxyglucose Positron Emission Tomography Imaging Provides a Noninvasive Measure of Carotid Plaque Inflammation in Patients
By Dr. Ahmed Tawakol et al
"Given the importance of inflammation in atherosclerosis, authors sought to determine if atherosclerotic plaque inflammation could be measured noninvasively in humans using positron emission tomography (PET). Seventeen patients with severe carotid stenoses underwent FDG-PET imaging 3 h after FDG administration (13 to 25 mCi), after which carotid plaque FDG uptake was determined as the ratio of plaque to blood activity (target to background ratio, TBR). Less than 1 month after imaging, subjects underwent CEA, after which carotid specimens were processed to identify macrophages (staining with anti-CD68 antibodies). There was a significant correlation between the PET signal from the carotid plaques and the macrophage staining from the corresponding histologic sections. Authors established that FDG-PET imaging can be used to assess the severity of inflammation in carotid plaques in patients."