In an article- Hippocampal atrophy in Alzheimer disease: age matters by Van de Pol LA et al in Neurology 2006 Jan 24;66(2):236-8. Hippocampal atrophy is a marker of Alzheimer disease (AD). It remains unclear whether this holds true for younger patients as well. Hippocampal volume was measured by MRI. Aging and AD were independently associated with smaller hippocampal volume. Both young and old AD patients have hippocampal atrophy abnormal for age. Age-dependent criteria for hippocampal atrophy, suggestive of AD, are needed.
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